Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common

• Main Authors: White, Nicholas J, Guo Qiao, Li, Qi, Gao, Luzzatto, Lucio
• Other Authors: Mahidol University. Faculty of Tropical Medicine. Tropical Medicine Research Unit
• Format: Article
• Language: English
• Published: 2017
• Subjects: Plasmodium falciparum; gametocytocide; primaquine; G6PD; Open Access article
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/2803
• Institution: Mahidol University

In areas of low malaria transmission, it is currently recommended that a single dose of primaquine (0.75 mg base/kg; 45 mg adult dose) be added to artemisinin combination treatment (ACT) in acute falciparum malaria to block malaria transmission. Review of studies of transmission-blocking activity...