Physicochemical characteristics, cytotoxicity, and antioxidant activity of three lipid nanoparticulate formulations of alpha-lipoic acid

• Main Authors: Uracha Ruktanonchai, Piyawan Bejrapha, Usawadee Sakulkhu, Praneet Opanasopit, Nuntavan Bunyapraphatsara, Varaporn Junyaprasert, Satit Puttipipatkhachorn
• Other Authors: Thailand National Science and Technology Development Agency
• Format: Article
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/28328
• Institution: Mahidol University

Exogenously supplied alpha-lipoic acid (LA) has proven to be effective as an antioxidant. In an effort to develop a water-soluble formulation for topical administration, LA was formulated in the form of solid lipid nanoparticles (SLN), nanostructure lipid carriers (NLC), and nanoemulsion (NE) and ch...