Stepwise acquisition of pyrimethamine resistance in the malaria parasite

Stepwise acquisition of pyrimethamine resistance in the malaria parasite

The spread of high-level pyrimethamine resistance in Africa threatens to curtail the therapeutic lifetime of antifolate antimalarials. We studied the possible evolutionary pathways in the evolution of pyrimethamine resistance using an approach in which all possible mutational intermediates were crea...

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Bibliographic Details
Main Authors: Elena R. Lozovsky, Thanat Chookajorn, Kyle M. Brown, Mallika Imwong, Philip J. Shaw, Sumalee Kamchonwongpaisan, Daniel E. Neafsey, Daniel M. Weinreich, Daniel L. Hartl
Other Authors: Harvard University
Format: Article
Published: 2018
Subjects:
Multidisciplinary
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/28388
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/28388

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