A selective sweep driven by pyrimethamine treatment in Southeast Asian malaria parasites

• Main Authors: Shalini Nair, Jeff T. Williams, Alan Brockman, Lucy Paiphun, Mayfong Mayxay, Paul N. Newton, Jean Paul Guthmann, Frank M. Smithuis, Tran Tinh Hien, Nicholas J. White, François Nosten, Tim J.C. Anderson
• Other Authors: Texas Biomedical Research Institute
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/20623
• Institution: Mahidol University

Malaria parasites (Plasmodium falciparum) provide an excellent system in which to study the genomic effects of strong selection in a recombining eukaryote because the rapid spread of resistance to multiple drugs during the last the past 50 years has been well documented, the full genome sequence and...