Recurrent gene amplification and soft selective sweeps during evolution of multidrug resistance in malaria parasites

• Main Authors: Shalini Nair, Denae Nash, Daniel Sudimack, Anchalee Jaidee, Marion Barends, Anne Catrin Uhlemann, Sanjeev Krishna, François Nosten, Tim J.C. Anderson
• Other Authors: Texas Biomedical Research Institute
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/24036
• Institution: Mahidol University

When selection is strong and beneficial alleles have a single origin, local reductions in genetic diversity are expected. However, when beneficial alleles have multiple origins or were segregating in the population prior to a change in selection regime, the impact on genetic diversity may be less cl...