Molecular and pharmacological determinants of the therapeutic response to artemether-lumefentrine in multidrug-resistant Plasmodium falciparum malaria

• Main Authors: Rie N. Price, Anne Catrin Uhlemann, Michela Van Vugt, Al Brockman, Robert Hutagalung, Shalini Nair, Denae Nash, Pratap Singhasivanon, Tim J.C. Anderson, Sanjeev Krishna, Nicholas J. White, François Noston
• Other Authors: John Radcliffe Hospital
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/23744
• Institution: Mahidol University

Background. Our study examined the relative contributions of host, pharmacokinetic, and parasitological factors in determining the therapeutic response to artemether-lumefantrine (AL). Methods. On the northwest border of Thailand, patients with uncomplicated Plasmodium falciparum malaria were enroll...