Evidence for soft selective sweeps in the evolution of pneumococcal multidrug resistance and vaccine escape

• Main Authors: Nicholas J. Croucher, Claire Chewapreecha, William P. Hanage, Simon R. Harris, Lesley McGee, Mark Van Der Linden, Jae Hoon Song, Kwan Soo Ko, Herminia De Lencastre, Claudia Turner, Fan Yang, Raquel Sa-Leao, Bernard Beall, Keith P. Klugman, Julian Parkhill, Paul Turner, Stephen D. Bentley
• Other Authors: Harvard School of Public Health
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/33176
• Institution: Mahidol University

Themultidrug-resistant Streptococcus pneumoniae Taiwan19F-14, orPMEN14, clone was first observed with a 19F serotype, which is targeted by the heptavalent polysaccharide conjugate vaccine (PCV7). However, "vaccine escape" PMEN14 isolates with a 19A serotype became an increasingly important...