Selection strength and hitchhiking around two anti-malarial resistance genes

• Main Authors: Denae Nash, Shalini Nair, Mayfong Mayxay, Paul N. Newton, Jean Paul Guthmann, François Nosten, Tim J.C. Anderson
• Other Authors: Texas Biomedical Research Institute
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Environmental Science; Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/16209
• Institution: Mahidol University

Neutral mutations may hitchhike to high frequency when they are situated close to sites under positive selection, generating local reductions in genetic diversity. This process is thought to be an important determinant of levels of genomic variation in natural populations. The size of genome regions...