Development and optimization of micro/nanoporous osmotic pump tablets
Micro/nanoporous osmotic pump tablets coated with cellulose acetate containing polyvinylpyrolidone (PVP) as pore formers were fabricated. Propranolol hydrochloride was used as a model drug in this study. Formulation optimization based on USP 31 requirements was conducted following a central composit...
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th-mahidol.284962018-09-24T16:41:43Z Development and optimization of micro/nanoporous osmotic pump tablets Siracha Tuntikulwattana Ampol Mitrevej Teerakiat Kerdcharoen Desmond B. Williams Nuttanan Sinchaipanid Mahidol University University of South Australia Agricultural and Biological Sciences Pharmacology, Toxicology and Pharmaceutics Micro/nanoporous osmotic pump tablets coated with cellulose acetate containing polyvinylpyrolidone (PVP) as pore formers were fabricated. Propranolol hydrochloride was used as a model drug in this study. Formulation optimization based on USP 31 requirements was conducted following a central composite design using a two-level factorial plan involving two membrane variables (pore former and coating levels). Effect of molecular weight of pore former (PVP K30 and PVP K90) was also evaluated. Responses of drug release to the variables were analyzed using statistical software (MINITAB 14). Scanning electron microscopy and atomic force microscopy showed that the pores formed by PVP. The drug release was dependent on the molecular weight and concentration of PVP and the level of coating. The results showed that acceptable 12-h profile could be achieved with only specific range of PVP K30-containing membrane at the defined membrane thickness. However, satisfactory 24-h profile could be accomplished by both PVP K30 and PVP K90-containing membrane at the range and membrane thickness tested. Preparation and testing of the optimized formulation showed a good correlation between predicted and observed values. © 2010 American Association of Pharmaceutical Scientists. 2018-09-24T08:38:40Z 2018-09-24T08:38:40Z 2010-06-01 Article AAPS PharmSciTech. Vol.11, No.2 (2010), 924-935 10.1208/s12249-010-9446-4 15309932 2-s2.0-77954818612 https://repository.li.mahidol.ac.th/handle/123456789/28496 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954818612&origin=inward |
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Agricultural and Biological Sciences Pharmacology, Toxicology and Pharmaceutics Siracha Tuntikulwattana Ampol Mitrevej Teerakiat Kerdcharoen Desmond B. Williams Nuttanan Sinchaipanid Development and optimization of micro/nanoporous osmotic pump tablets |
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Micro/nanoporous osmotic pump tablets coated with cellulose acetate containing polyvinylpyrolidone (PVP) as pore formers were fabricated. Propranolol hydrochloride was used as a model drug in this study. Formulation optimization based on USP 31 requirements was conducted following a central composite design using a two-level factorial plan involving two membrane variables (pore former and coating levels). Effect of molecular weight of pore former (PVP K30 and PVP K90) was also evaluated. Responses of drug release to the variables were analyzed using statistical software (MINITAB 14). Scanning electron microscopy and atomic force microscopy showed that the pores formed by PVP. The drug release was dependent on the molecular weight and concentration of PVP and the level of coating. The results showed that acceptable 12-h profile could be achieved with only specific range of PVP K30-containing membrane at the defined membrane thickness. However, satisfactory 24-h profile could be accomplished by both PVP K30 and PVP K90-containing membrane at the range and membrane thickness tested. Preparation and testing of the optimized formulation showed a good correlation between predicted and observed values. © 2010 American Association of Pharmaceutical Scientists. |
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Mahidol University |
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Mahidol University Siracha Tuntikulwattana Ampol Mitrevej Teerakiat Kerdcharoen Desmond B. Williams Nuttanan Sinchaipanid |
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Siracha Tuntikulwattana Ampol Mitrevej Teerakiat Kerdcharoen Desmond B. Williams Nuttanan Sinchaipanid |
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Siracha Tuntikulwattana |
title |
Development and optimization of micro/nanoporous osmotic pump tablets |
title_short |
Development and optimization of micro/nanoporous osmotic pump tablets |
title_full |
Development and optimization of micro/nanoporous osmotic pump tablets |
title_fullStr |
Development and optimization of micro/nanoporous osmotic pump tablets |
title_full_unstemmed |
Development and optimization of micro/nanoporous osmotic pump tablets |
title_sort |
development and optimization of micro/nanoporous osmotic pump tablets |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/28496 |
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1763493421133070336 |