A dynamic model of pneumococcal infection in the United States: Implications for prevention through vaccination

• Main Authors: Thierry Van Effelterre, Matthew R. Moore, Frederik Fierens, Cynthia G. Whitney, Lisa White, Stephen I. Pelton, William P. Hausdorff
• Other Authors: Glaxosmithkline Biologicals S.A.
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/28713
• Institution: Mahidol University

Universal infant vaccination with the 7-valent pneumococcal conjugate vaccine (PCV7) has nearly eliminated PCV7-serotype invasive pneumococcal disease (IPD) in young U.S. children, but has been accompanied by increases in the incidence of serotype 19A IPD. Because antibiotic-non-susceptible 19A has...