Facile oxidative hydrolysis of acetals to esters using hypervalent iodine(III)/LiBr combination in water

• Main Authors: Waraporn Panchan, Supanimit Chiampanichayakul, Deanna L. Snyder, Siriporn Yodbuntung, Manat Pohmakotr, Vichai Reutrakul, Thaworn Jaipetch, Chutima Kuhakarn
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/28738

The combination of (diacetoxy)iodobenzene (PhI(OAc)2, DIB) and lithium bromide (LiBr) efficiently oxidized cyclic and acyclic acetals to the corresponding hydroxyalkyl carboxylic esters and simple esters in good to excellent yields. The merits of this reaction are that it employs commercially availa...