Detecting genotyping error using measures of degree of hardy-weinberg disequilibrium

• Main Authors: John Attia, Ammarin Thakkinstian, Patrick McElduff, Elizabeth Milne, Somer Dawson, Rodney J. Scott, Nicholas De Klerk, Bruce Armstrong, John Thompson
• Other Authors: University of Newcastle, Australia
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Mathematics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/28761
• Institution: Mahidol University

Tests for Hardy-Weinberg equilibrium (HWE) have been used to detect genotyping error, but those tests have low power unless the sample size is very large. We assessed the performance of measures of departure from HWE as an alternative way of screening for genotyping error. Three measures of the degr...