Choosing between per-genotype, per-allele, and trend approaches for initial detection of gene-disease association

• Main Authors: Ammarin Thakkinstian, John R. Thompson, Cosetta Minelli, John Attia
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Decision Sciences; Mathematics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/27507

There are a number of approaches to detect candidate gene-disease associations including: (i) 'pergenotype', which looks for any difference across the genotype groups without making any assumptions about the direction of the effect or the genetic model; (ii) 'per-allele', which a...