α-Glucosidase inhibitory, aromatase inhibitory, and antiplasmodial activities of a biflavonoid gb1 from garcinia kola stem bark

α-Glucosidase inhibitory, aromatase inhibitory, and antiplasmodial activities of a biflavonoid gb1 from garcinia kola stem bark

The biflavonoid, 3,4,4,5,5,7,7-heptahydroxy-3,8-biflavanone, known as GB1 (1), was isolated as a major constituent from Garcinia kola stem bark. GB1 (1) exhibited -glucosidase and aromatase inhibitory activities, as well as antiplasmodial activity, but was not toxic against cell lines tested. GB1 (1...

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Bibliographic Details
Main Authors: Bassey S. Antia, Acharavadee Pansanit, Okon D. Ekpa, Udofot J. Ekpe, Chulabhorn Mahidol, Prasat Kittakoop
Other Authors: Chulabhorn Research Institute
Format: Article
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/28781
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Institution: Mahidol University
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Summary:The biflavonoid, 3,4,4,5,5,7,7-heptahydroxy-3,8-biflavanone, known as GB1 (1), was isolated as a major constituent from Garcinia kola stem bark. GB1 (1) exhibited -glucosidase and aromatase inhibitory activities, as well as antiplasmodial activity, but was not toxic against cell lines tested. GB1 (1) may be a potential dietary supplement or phytomedicine for the prevention of breast cancer and type 2 diabetes mellitus. © Georg Thieme Verlag KG Stuttgart · New York.

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