α-Glucosidase inhibitory, aromatase inhibitory, and antiplasmodial activities of a biflavonoid gb1 from garcinia kola stem bark

• Main Authors: Bassey S. Antia, Acharavadee Pansanit, Okon D. Ekpa, Udofot J. Ekpe, Chulabhorn Mahidol, Prasat Kittakoop
• Other Authors: Chulabhorn Research Institute
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/28781
• Institution: Mahidol University

The biflavonoid, 3,4,4,5,5,7,7-heptahydroxy-3,8-biflavanone, known as GB1 (1), was isolated as a major constituent from Garcinia kola stem bark. GB1 (1) exhibited -glucosidase and aromatase inhibitory activities, as well as antiplasmodial activity, but was not toxic against cell lines tested. GB1 (1...