Within-host evolution of Burkholderia pseudomallei in four cases of acute melioidosis

• Main Authors: Erin P. Price, Heidie M. Hornstra, Direk Limmathurotsakul, Tamara L. Max, Derek S. Sarovich, Amy J. Vogler, Julia L. Dale, Jennifer L. Ginther, Benjamin Leadem, Rebecca E. Colman, Jeffrey T. Foster, Apichai Tuanyok, David M. Wagner, Sharon J. Peacock, Talima Pearson, Paul Keim
• Other Authors: Northern Arizona University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/28830
• Institution: Mahidol University

Little is currently known about bacterial pathogen evolution and adaptation within the host during acute infection. Previous studies of Burkholderia pseudomallei, the etiologic agent of melioidosis, have shown that this opportunistic pathogen mutates rapidly both in vitro and in vivo at tandemly rep...