Arterolane, a new synthetic trioxolane for treatment of uncomplicated Plasmodium falciparum malaria: A phase II, multicenter, randomized, dose-finding clinical trial

• Main Authors: Neena Valecha, Sornchai Looareesuwan, Andreas Martensson, Salim Mohammed Abdulla, Srivicha Krudsood, Noppadon Tangpukdee, Sanjib Mohanty, Saroj K. Mishra, P. K. Tyagi, S. K. Sharma, Joerg Moehrle, Anirudh Gautam, Arjun Roy, Jyoti K. Paliwal, Monica Kothari, Nilanjan Saha, Aditya P. Dash, Anders Björkman
• Other Authors: National Institute of Malaria Research India
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/29532
• Institution: Mahidol University

Background: Drug-resistant Plasmodium falciparum malaria necessitates development of novel drugs for treatment. The present study assessed the efficacy and safety of 3 dose levels of arterolane (RBx 11160), a synthetic trioxolane, for treatment of acute uncomplicated falciparum malaria. Methods: In...