Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria

• Main Authors: Elizabeth A. Ashley, Kasia Stepniewska, Niklas Lindegardh, Anna Annerberg, Joel Tarning, Rose McGready, Lucy Phaiphun, Pratap Singhasivanon, Nicholas J. White, François Nosten
• Other Authors: Shoklo Malaria Research Unit
• Format: Article
• Published: 2018
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/29865
• Institution: Mahidol University

Purpose Dihydroartemisinin-piperaquine (DP) is a fixeddose artemisinin-based combination treatment. Field pharmacokinetic studies would be simplified and facilitated by being able to use small volume capillary assays rather than venous blood. The aim of this study was to describe the relationship be...