Spiroindolones, a potent compound class for the treatment of malaria
Recent reports of increased tolerance to artemisinin derivatives - the most recently adopted class of antimalarials - have prompted a need for new treatments. The spirotetrahydro-β-carbolines, or spiroindolones, are potent drugs that kill the blood stages of Plasmodium falciparum and Plasmodium viva...
Saved in:
Main Authors: | Matthias Rottmann, Case McNamara, Bryan K.S. Yeung, Marcus C.S. Lee, Bin Zou, Bruce Russell, Patrick Seitz, David M. Plouffe, Neekesh V. Dharia, Jocelyn Tan, Steven B. Cohen, Kathryn R. Spencer, Gonzalo E. González-Páez, Suresh B. Lakshminarayana, Anne Goh, Rossarin Suwanarusk, Timothy Jegla, Esther K. Schmitt, Hans Peter Beck, Reto Brun, Francois Nosten, Laurent Renia, Veronique Dartois, Thomas H. Keller, David A. Fidock, Elizabeth A. Winzeler, Thierry T. Diagana |
---|---|
Other Authors: | Swiss Tropical and Public Health Institute (Swiss TPH) |
Format: | Article |
Published: |
2018
|
Subjects: | |
Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/29981 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Mahidol University |
Similar Items
-
Pharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model
by: Lakshminarayana S.B., et al.
Published: (2016) -
Spiroindolone KAE609 for falciparum and vivax malaria
by: Nicholas J. White, et al.
Published: (2018) -
Mechanistic studies of anti-malarial spiroindolones and synthesis and structure-activity relationship studies of an inhibitor of dengue proliferation
by: YAP PEILING
Published: (2011) -
A first-in-human randomized, double-blind, placebo-controlled, single- And multiple-ascending oral dose study of novel antimalarial spiroindolone KAE609 (cipargamin) to assess its safety, tolerability, and pharmacokinetics in healthy adult volunteers
by: Leong, F.J, et al.
Published: (2020) -
Le Defi Mondial
by: McNamara, S.J.
Published: (1983)