Nonlinear Mixed-Effects Modelling of In Vitro Drug Susceptibility and Molecular Correlates of Multidrug Resistant Plasmodium falciparum

• Main Authors: Julie A. Simpson, Kris M. Jamsen, Tim J.C. Anderson, Sophie Zaloumis, Shalini Nair, Charles Woodrow, Nicholas J. White, Francois Nosten, Ric N. Price
• Other Authors: University of Melbourne
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/31004
• Institution: Mahidol University

The analysis of in vitro anti-malarial drug susceptibility testing is vulnerable to the effects of different statistical approaches and selection biases. These confounding factors were assessed with respect to pfmdr1 gene mutation and amplification in 490 clinical isolates. Two statistical approache...