Flavans from Desmos cochinchinensis as potent aromatase inhibitors

Flavans from Desmos cochinchinensis as potent aromatase inhibitors

Flavans from the roots of Desmos cochinchinensis exhibited potent aromatase inhibitory activity at nanomolar levels, and could be leads for the development of anti-aromatase drugs. In addition, these aromatase inhibitors did not show pronounced cytotoxic activity. Flavans exert their inhibitory acti...

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Main Authors: Vilailak Prachyawarakorn, Suwannee Sangpetsiripan, Panida Surawatanawong, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop
Other Authors: Chulabhorn Research Institute
Format: Article
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/31151
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Institution: Mahidol University
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spelling th-mahidol.311512018-10-19T12:42:36Z Flavans from Desmos cochinchinensis as potent aromatase inhibitors Vilailak Prachyawarakorn Suwannee Sangpetsiripan Panida Surawatanawong Chulabhorn Mahidol Somsak Ruchirawat Prasat Kittakoop Chulabhorn Research Institute Mahidol University Chulabhorn Graduate Institute South Carolina Commission on Higher Education Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics Flavans from the roots of Desmos cochinchinensis exhibited potent aromatase inhibitory activity at nanomolar levels, and could be leads for the development of anti-aromatase drugs. In addition, these aromatase inhibitors did not show pronounced cytotoxic activity. Flavans exert their inhibitory activity through binding, as revealed by molecular docking studies, with aromatase at Arg115, Met374, and Leu477; the C-7 hydroxyl (or methoxyl) forms hydrogen bonds with Met374 and Arg115 of aromatase. © 2013 The Royal Society of Chemistry. 2018-10-19T04:33:44Z 2018-10-19T04:33:44Z 2013-12-01 Article MedChemComm. Vol.4, No.12 (2013), 1590-1596 10.1039/c3md00166k 20402511 20402503 2-s2.0-84888142695 https://repository.li.mahidol.ac.th/handle/123456789/31151 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84888142695&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
Vilailak Prachyawarakorn
Suwannee Sangpetsiripan
Panida Surawatanawong
Chulabhorn Mahidol
Somsak Ruchirawat
Prasat Kittakoop
Flavans from Desmos cochinchinensis as potent aromatase inhibitors
description Flavans from the roots of Desmos cochinchinensis exhibited potent aromatase inhibitory activity at nanomolar levels, and could be leads for the development of anti-aromatase drugs. In addition, these aromatase inhibitors did not show pronounced cytotoxic activity. Flavans exert their inhibitory activity through binding, as revealed by molecular docking studies, with aromatase at Arg115, Met374, and Leu477; the C-7 hydroxyl (or methoxyl) forms hydrogen bonds with Met374 and Arg115 of aromatase. © 2013 The Royal Society of Chemistry.
author2 Chulabhorn Research Institute
author_facet Chulabhorn Research Institute
Vilailak Prachyawarakorn
Suwannee Sangpetsiripan
Panida Surawatanawong
Chulabhorn Mahidol
Somsak Ruchirawat
Prasat Kittakoop
format Article
author Vilailak Prachyawarakorn
Suwannee Sangpetsiripan
Panida Surawatanawong
Chulabhorn Mahidol
Somsak Ruchirawat
Prasat Kittakoop
author_sort Vilailak Prachyawarakorn
title Flavans from Desmos cochinchinensis as potent aromatase inhibitors
title_short Flavans from Desmos cochinchinensis as potent aromatase inhibitors
title_full Flavans from Desmos cochinchinensis as potent aromatase inhibitors
title_fullStr Flavans from Desmos cochinchinensis as potent aromatase inhibitors
title_full_unstemmed Flavans from Desmos cochinchinensis as potent aromatase inhibitors
title_sort flavans from desmos cochinchinensis as potent aromatase inhibitors
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/31151
_version_ 1763496944452239360

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