Base excision DNA repair defect in thioredoxin-1 (Trx1)-deficient cells

• Main Authors: Hye Lim Kim, Preeyaporn Koedrith, Sang Min Lee, Yeo Jin Kim, Young Rok Seo
• Other Authors: Dongguk University, Seoul
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Environmental Science
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/31176
• Institution: Mahidol University

Thioredoxin-1 (Trx1) is an antioxidant enzyme with a protective role in the removal of oxidative stress. We investigated the mechanism by which the redox modulator Trx1 affects base excision repair (BER) activity to understand the protective role of Trx1. We constructed a Trx1 knockdown system to de...