Role of Calcium sensing receptor (CaSR) in tumorigenesis

• Main Authors: Navneet Singh, Moltira Promkan, Guangming Liu, James Varani, Subhas Chakrabarty
• Other Authors: Southern Illinois University School of Medicine
• Format: Conference or Workshop Item
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/31417
• Institution: Mahidol University

The extracellular Ca2+-sensing receptor (CaSR) is a robust promoter of differentiation in colonic epithelial cells and functions as a tumor suppressor in colon cancer. CaSR mediates its biologic effects through diverse mechanisms. Loss of CaSR expression activates a myriad of stem cell-like molecula...