Long-range distances in amyloid fibrils of α-synuclein from PELDOR spectroscopy

• Main Authors: S. Pornsuwan, K. Giller, D. Riedel, S. Becker, C. Griesinger, M. Bennati
• Other Authors: Max Planck Institute for Biophysical Chemistry (Karl Friedrich Bonhoeffer Institute)
• Format: Article
• Published: 2018
• Subjects: Chemical Engineering; Chemistry
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/31466
• Institution: Mahidol University

Distance measurements: Pulsed EPR distance measurements combined with strategic spin labeling provide structural constraints at the molecular level for the fold of α-synuclein in amyloid fibrils (see picture; r=distance). The detection of interstrand distances in fibrils will potentially make it pos...