Diterpene glycosides from Holothuria scabra exert the α-synuclein degradation and neuroprotection against α-synuclein-Mediated neurodegeneration in C. elegans model

• Main Authors: Pawanrat Chalorak, Nilubon Sornkaew, Preeyanuch Manohong, Nakorn Niamnont, Nawaphat Malaiwong, Tanapol Limboonreung, Prasert Sobhon, Michael Aschner, Krai Meemon
• Other Authors: King Mongkut's Institute of Technology Ladkrabang
• Format: Article
• Published: 2022
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/78942
• Institution: Mahidol University

Ethnopharmacological relevance: Holothuria (Metriatyla) scabra Jaeger (H. scabra), sea cucumber, is the marine organism that has been used as traditional food and medicine to gain the health benefits since ancient time. Although our recent studies have shown that crude extracts from H. scabra exhibi...