Parasite clearance rates in Upper Myanmar indicate a distinctive artemisinin resistance phenotype: a therapeutic efficacy study

• Main Authors: Tun, Kyaw Myo, Atthanee Jeeyapant, Mallika Imwong, Min Thein, Sai Soe Moe Aung, Hlaing, Tin Maung, Prayoon Yuentrakul, Cholrawee Promnarate, Mehul Dhorda, Woodrow, Charles J., Dondorp, Arjen M., Ashley, Elizabeth A., Smithuis, Frank M., White, Nicholas J., Day, Nicholas P. J.
• Other Authors: Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit
• Format: Article
• Language: English
• Published: 2017
• Subjects: Open Access article; Plasmodium falciparum; Artemisinin resistance; Kelch 13 propeller; Parasite clearance half-life; Myanmar
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/3150
• Institution: Mahidol University

Background: Artemisinin resistance in Plasmodium falciparum extends across Southeast Asia where it is associated with worsening partner drug resistance and a decline in the efficacy of frontline artemisinin-based combination therapy. Dihydroartemisinin-piperaquine (DP) is an essential component of...