The pathogenesis of dengue
Purpose of Review: Dengue is one of the most rapidly spreading vector-borne diseases in the world, with the incidence increasing 30-fold in the past 50 years. There are currently no licensed treatments or vaccines for dengue. This review covers the recent advances in our understanding of dengue path...
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th-mahidol.323122018-10-19T12:23:32Z The pathogenesis of dengue Sophie Yacoub Juthathip Mongkolsapaya Gavin Screaton Imperial College London University of Oxford Mahidol University Medicine Purpose of Review: Dengue is one of the most rapidly spreading vector-borne diseases in the world, with the incidence increasing 30-fold in the past 50 years. There are currently no licensed treatments or vaccines for dengue. This review covers the recent advances in our understanding of dengue pathogenesis, including host and viral determinants. RECENT FINDINGS: The pathogenesis of severe dengue is thought to be immune-mediated due to the timing of the clinical manifestations and higher incidence in secondary infections with a heterologous serotype. Recent evidence has provided further information of neutralizing versus enhancing monoclonal antibodies and their target epitopes on the dengue virion, which has major implications for vaccine design. The role of T-cell immunopathology has also been advanced with recent evidence of cross-reactive high pro-inflammatory cytokine producing T cells predominating in severe dengue. Recent large genome-wide association studies have identified specific susceptibility loci associated with severe disease. Epidemiological studies have served to define certain at-risk groups and specific viral virulence factors have recently been described. SUMMARY: The pathogenesis of dengue is likely to be a complex interplay of host immunity and genetic predisposition combined with certain viral virulence factors. Better understanding of the underlying mechanisms leading to severe dengue is crucial if we are to develop prognostic markers, novel diagnostics and therapeutics and ultimately a balanced and safe vaccine. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins. 2018-10-19T05:23:32Z 2018-10-19T05:23:32Z 2013-06-01 Review Current Opinion in Infectious Diseases. Vol.26, No.3 (2013), 284-289 10.1097/QCO.0b013e32835fb938 14736527 09517375 2-s2.0-84876818202 https://repository.li.mahidol.ac.th/handle/123456789/32312 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84876818202&origin=inward |
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Medicine Sophie Yacoub Juthathip Mongkolsapaya Gavin Screaton The pathogenesis of dengue |
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Purpose of Review: Dengue is one of the most rapidly spreading vector-borne diseases in the world, with the incidence increasing 30-fold in the past 50 years. There are currently no licensed treatments or vaccines for dengue. This review covers the recent advances in our understanding of dengue pathogenesis, including host and viral determinants. RECENT FINDINGS: The pathogenesis of severe dengue is thought to be immune-mediated due to the timing of the clinical manifestations and higher incidence in secondary infections with a heterologous serotype. Recent evidence has provided further information of neutralizing versus enhancing monoclonal antibodies and their target epitopes on the dengue virion, which has major implications for vaccine design. The role of T-cell immunopathology has also been advanced with recent evidence of cross-reactive high pro-inflammatory cytokine producing T cells predominating in severe dengue. Recent large genome-wide association studies have identified specific susceptibility loci associated with severe disease. Epidemiological studies have served to define certain at-risk groups and specific viral virulence factors have recently been described. SUMMARY: The pathogenesis of dengue is likely to be a complex interplay of host immunity and genetic predisposition combined with certain viral virulence factors. Better understanding of the underlying mechanisms leading to severe dengue is crucial if we are to develop prognostic markers, novel diagnostics and therapeutics and ultimately a balanced and safe vaccine. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
author2 |
Imperial College London |
author_facet |
Imperial College London Sophie Yacoub Juthathip Mongkolsapaya Gavin Screaton |
format |
Review |
author |
Sophie Yacoub Juthathip Mongkolsapaya Gavin Screaton |
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Sophie Yacoub |
title |
The pathogenesis of dengue |
title_short |
The pathogenesis of dengue |
title_full |
The pathogenesis of dengue |
title_fullStr |
The pathogenesis of dengue |
title_full_unstemmed |
The pathogenesis of dengue |
title_sort |
pathogenesis of dengue |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/32312 |
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1763488646050086912 |