Lupinifolin, a bioactive flavanone from Myriopteron extensum (Wight) K. Schum. stem

• Main Authors: Noppamas Soonthornchareonnon, Lersak Ubonopas, Songsri Kaewsuwan, Mansong Wuttiudomlert
• Other Authors: Mahidol University. Faculty of Pharmacy. Department of Pharmacognosy
• Format: Original Article
• Language: English
• Published: 2017
• Subjects: Lupinifolin; flavanone; Myriopteron extensum; anti-HSV-1; Thai Journal of Phytopharmacy; วารสารสมุนไพร; Open Access article
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/3253
• Institution: Mahidol University

Lupinifolin was isolated from the crude hexane extract of Myriopteron extensum stem. Structural identification was carried on by spectroscopic methods and the comparison of its mp,[α]27 D, 1H and 13C NMR spectroscopic data with published values and biological activities (anti-herpes simplex virus type 1, antimycobacterial, antibacterial, antifungal, antiplasmodial, anti-inflammatory, antioxidative and cytotoxicity) of ethanolic extract and lupinifolin were tested. Lupinifolin and the ethanolic extract exhibited strongly active anti-HSV-1 with IC50 values of 0.3 and 0.1 μg/ml, respectively. Lupinifolin showed selective cytotoxicity towards breast cancer (BC) with IC50values of 3.3 μg/ml and expressed weakly cytotoxic activity towards KB and NCI-H187. Lupinifolin also expressed moderate antimycobacterial activity with MIC at 12.5 μg/ml. Lupinifolin was inactive against Candida albicans and dermatophytes while the ethanolic extract inhibited all tested dermatophytes with the concentration of 6.73 mg/disc. Both of them showed moderate active to Gram-positive bacteria and no activity against Gram-negative bacteria. Lupinifolin and the ethanolic extract showed inactive in the DPPH radical scavenging, antiplasmodial and anti-inflammatory assay at concentration 200, 10 and 50 μg/ml, respectively.