The Effect of Dosing Regimens on the Antimalarial Efficacy of Dihydroartemisinin-Piperaquine: A Pooled Analysis of Individual Patient Data

• Main Authors: Jane Achan, Ishag Adam, Emmanuel Arinaitwe, Elizabeth A. Ashley, Ghulam Rahim Awab, Mamadou S. Ba, Karen I. Barnes, Quique Bassat, Steffen Borrmann, Teun Bousema, Prabin Dahal, Umberto D'Alessandro, Timothy M.E. Davis, Arjen M. Dondorp, Grant Dorsey, Chris J. Drakeley, Caterina I. Fanello, Babacar Faye, Jennifer A. Flegg, Oumar Gaye, Peter W. Gething, Raquel González, Philippe J. Guerin, Simon I. Hay, Tran T. Hien, Bart Janssens, Moses R. Kamya, Corine Karema, Harin A. Karunajeewa, Moussa Koné, Bertrand Lell, Kevin Marsh, Mayfong Mayxay, Clara Menéndez, Petra F. Mens, Martin Meremikwu, Clarissa Moreira, Ivo Mueller, Carolyn Nabasumba, Michael Nambozi, Jean Louis Ndiaye, Paul N. Newton, Thuy Nhien Nguyen, Francois Nosten, Christian Nsanzabana, Sabah A. Omar, Jean Bosco Ouédraogo, Louis K. Penali, Mbaye Pene, Aung Pyae Phyo, Patrice Piola, Ric N. Price, P. Sasithon, Philip J. Rosenthal, Albert Same-Ekobo, Patrick Sawa, Henk D.F.H. Schallig, Seif A. Shekalaghe, Carol Hopkins Sibley, Jeff Smith, Frank Smithuis, Anyirékun Fabrice Somé, Kasia Stepniewska, Ambrose O. Talisuna, Joel Tarning, Emiliana Tjitra, Roger C.K. Tine
• Other Authors: Uganda Malaria Surveillance Project
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/32709
• Institution: Mahidol University

Background:Dihydroartemisinin-piperaquine (DP) is increasingly recommended for antimalarial treatment in many endemic countries; however, concerns have been raised over its potential under dosing in young children. We investigated the influence of different dosing schedules on DP's clinical eff...