Characterization of cromolyn sodium hydrates and its formulation by²³Na-multiquantum and magic-angle spinning nuclear magnetic resonance spectroscopy

• Main Authors: Makoto Umino, Kenjirou Higashi, Hyuma Masu, Waree Limwikrant, Keiji Yamamoto, Kunikazu Moribe
• Other Authors: Chiba University
• Format: Article
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/32762
• Institution: Mahidol University

We characterized cromolyn sodium (CS) hydrates and evaluated their molecular states in low-dose formulations using Na-multiquantum magic-angle spinning (MQMAS) nuclear magnetic resonance (NMR) analysis. Two CS hydrates, low-water-content hydrated form and high-water-content hydrated form containing...