Chloroquine is grossly under dosed in young children with malaria: Implications for drug resistance

• Main Authors: Johan Ursing, Staffan Eksborg, Lars Rombo, Yngve Bergqvist, Daniel Blessborn, Amabelia Rodrigues, Poul Erik Kofoed
• Other Authors: Indepth Network
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/33064
• Institution: Mahidol University

Background: Plasmodium falciparum malaria is treated with 25 mg/kg of chloroquine (CQ) irrespective of age. Theoretically, CQ should be dosed according to body surface area (BSA). The effect of dosing CQ according to BSA has not been determined but doubling the dose per kg doubled the efficacy of CQ...