Ablation of TrkB signalling in CCK neurons results in hypercortisolism and obesity

• Main Authors: Mirjam Geibel, Sylvia Badurek, Jacqueline M. Horn, Chinnavuth Vatanashevanopakorn, Juraj Koudelka, Claudia M. Wunderlich, Hella S. Brönneke, F. Thomas Wunderlich, Liliana Minichiello
• Other Authors: University of Oxford
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Physics and Astronomy
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/33287
• Institution: Mahidol University

Dysregulation of hypothalamic-pituitary-adrenal (HPA) axis activity leads to debilitating neuroendocrine or metabolic disorders such as Cushing's syndrome (CS). Glucocorticoids control HPA axis activity through negative feedback to the pituitary gland and the central nervous system (CNS). Howev...