Comparative outcome of Thai pediatric osteosarcoma treated with two protocols: The role of high-dose methotrexate (HDMTX) in a single institute experience

• Main Authors: Worawut Choeyprasert, Samart Pakakasama, Nongnuch Sirachainan, Duantida Songdej, Ampaiwan Chuansumrit, Usanarat Anurathapan, Suradej Hongeng, Adisak Nartthanarung
• Other Authors: Chiang Mai University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/33417
• Institution: Mahidol University

Background: High-dose methotrexate (HD-MTX) is recognized as an efficient component of therapy against pediatric osteosarcoma in combination with other drugs such as cisplatin (CDP), carboplatin (CBDCA), doxorubicin (ADM), etoposide (VP-16) and ifosfamide (IFO). Objectives: To demonstrate the feasib...