The association between perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant Thai women
Context: Thyroid hormone is critical for fetal neurodevelopment. Perchlorate and thiocyanate decrease thyroidal iodine uptake by competitively inhibiting the sodium/iodide symporter. It is clear that perchlorate and thiocyanate anions can influence thyroid function. However, as pollutants in the env...
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th-mahidol.334822018-11-09T10:01:16Z The association between perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant Thai women Natthinee Charatcharoenwitthaya Boonsong Ongphiphadhanakul Elizabeth N. Pearce Charintip Somprasit Athita Chanthasenanont Xuemei He Laor Chailurkit Lewis E. Braverman Faculty of Medicine, Thammasat University Mahidol University Boston University School of Medicine Biochemistry, Genetics and Molecular Biology Medicine Context: Thyroid hormone is critical for fetal neurodevelopment. Perchlorate and thiocyanate decrease thyroidal iodine uptake by competitively inhibiting the sodium/iodide symporter. It is clear that perchlorate and thiocyanate anions can influence thyroid function. However, as pollutants in the environment, their impact is conflicting. Objective: The objective was to determine the effects of environmental perchlorate and/or thiocyanate exposure on thyroid function in first-trimester pregnant women. Design and Patients: A cross-sectional study was conducted in 200 pregnant Thai women with a gestational age of 14 weeks or less. Measures: Urinary iodide, perchlorate, thiocyanate, and serum thyroid function tests were measured. Results: The women were aged 28.6 ± 6.1 years and the mean gestational age was 9.6 ± 2.7 weeks. Median urinary iodide, perchlorate, and thiocyanate concentrations were 153.5 μg/L, 1.9 μg/L, and 510.5 μg/L, respectively. Using Spearman's rank correlation analyses, there were positive correlations between serum TSH and urine perchlorate to creatinine (r = 0.20, P = .005) and TSH and thiocyanate to creatinine ratios (r = 0.22, P = .001). There were negative correlations between free T4and the perchlorate to creatinine ratio (r = -0.18, P = .01) and free T4and the thiocyanate to creatinine ratio (r = -0.19, P = .008). In multivariate analyses adjusting for log thiocyanate to creatinine ratio, log iodide to creatinine ratio, and gestational age, log perchlorate to creatinine ratio was positively associated with log TSH (P = .002) and inversely associated with log free T4(P = .002). Log thiocyanate to creatinine ratio was a significant positive predictor of log TSH (P = .02) in women with a urine iodide level of less than 100 μg/L. Conclusions: Low-level environmental exposure to perchlorate and thiocyanate is common in Thailand. Low-level exposure to perchlorate is positively associated with TSH and negatively associated with free T4in first-trimester pregnantwomenusing multivariate analyses. In multivariate analyses, thiocyanate exposure is also positively associated with TSH in a subgroup of pregnant women with low iodine excretion. Copyright © 2014 by the Endocrine Society. 2018-11-09T02:00:17Z 2018-11-09T02:00:17Z 2014-01-01 Article Journal of Clinical Endocrinology and Metabolism. Vol.99, No.7 (2014), 2365-2371 10.1210/jc.2013-3986 19457197 0021972X 2-s2.0-84904045293 https://repository.li.mahidol.ac.th/handle/123456789/33482 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904045293&origin=inward |
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Biochemistry, Genetics and Molecular Biology Medicine Natthinee Charatcharoenwitthaya Boonsong Ongphiphadhanakul Elizabeth N. Pearce Charintip Somprasit Athita Chanthasenanont Xuemei He Laor Chailurkit Lewis E. Braverman The association between perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant Thai women |
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Context: Thyroid hormone is critical for fetal neurodevelopment. Perchlorate and thiocyanate decrease thyroidal iodine uptake by competitively inhibiting the sodium/iodide symporter. It is clear that perchlorate and thiocyanate anions can influence thyroid function. However, as pollutants in the environment, their impact is conflicting. Objective: The objective was to determine the effects of environmental perchlorate and/or thiocyanate exposure on thyroid function in first-trimester pregnant women. Design and Patients: A cross-sectional study was conducted in 200 pregnant Thai women with a gestational age of 14 weeks or less. Measures: Urinary iodide, perchlorate, thiocyanate, and serum thyroid function tests were measured. Results: The women were aged 28.6 ± 6.1 years and the mean gestational age was 9.6 ± 2.7 weeks. Median urinary iodide, perchlorate, and thiocyanate concentrations were 153.5 μg/L, 1.9 μg/L, and 510.5 μg/L, respectively. Using Spearman's rank correlation analyses, there were positive correlations between serum TSH and urine perchlorate to creatinine (r = 0.20, P = .005) and TSH and thiocyanate to creatinine ratios (r = 0.22, P = .001). There were negative correlations between free T4and the perchlorate to creatinine ratio (r = -0.18, P = .01) and free T4and the thiocyanate to creatinine ratio (r = -0.19, P = .008). In multivariate analyses adjusting for log thiocyanate to creatinine ratio, log iodide to creatinine ratio, and gestational age, log perchlorate to creatinine ratio was positively associated with log TSH (P = .002) and inversely associated with log free T4(P = .002). Log thiocyanate to creatinine ratio was a significant positive predictor of log TSH (P = .02) in women with a urine iodide level of less than 100 μg/L. Conclusions: Low-level environmental exposure to perchlorate and thiocyanate is common in Thailand. Low-level exposure to perchlorate is positively associated with TSH and negatively associated with free T4in first-trimester pregnantwomenusing multivariate analyses. In multivariate analyses, thiocyanate exposure is also positively associated with TSH in a subgroup of pregnant women with low iodine excretion. Copyright © 2014 by the Endocrine Society. |
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Faculty of Medicine, Thammasat University |
author_facet |
Faculty of Medicine, Thammasat University Natthinee Charatcharoenwitthaya Boonsong Ongphiphadhanakul Elizabeth N. Pearce Charintip Somprasit Athita Chanthasenanont Xuemei He Laor Chailurkit Lewis E. Braverman |
format |
Article |
author |
Natthinee Charatcharoenwitthaya Boonsong Ongphiphadhanakul Elizabeth N. Pearce Charintip Somprasit Athita Chanthasenanont Xuemei He Laor Chailurkit Lewis E. Braverman |
author_sort |
Natthinee Charatcharoenwitthaya |
title |
The association between perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant Thai women |
title_short |
The association between perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant Thai women |
title_full |
The association between perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant Thai women |
title_fullStr |
The association between perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant Thai women |
title_full_unstemmed |
The association between perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant Thai women |
title_sort |
association between perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant thai women |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/33482 |
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1763490510925725696 |