Validation of a chloroquine-induced cell death mechanism for clinical use against malaria

• Main Authors: J. H. Ch'ng, Y. Q. Lee, S. Y. Gun, W. N. Chia, Z. W. Chang, L. K. Wong, K. T. Batty, B. Russell, F. Nosten, L. Renia, K. S.W. Tan
• Other Authors: National University of Singapore
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Neuroscience
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/33514
• Institution: Mahidol University

An alternative antimalarial pathway of an 'outdated' drug, chloroquine (CQ), may facilitate its return to the shrinking list of effective antimalarials. Conventionally, CQ is believed to interfere with hemozoin formation at nanomolar concentrations, but resistant parasites are able to effl...