Loop diuretics are open-channel blockers of the cystic fibrosis transmembrane conductance regulator with distinct kinetics

• Main Authors: Min Ju, Toby S. Scott-Ward, Jia Liu, Pissared Khuituan, Hongyu Li, Zhiwei Cai, Stephen M. Husbands, David N. Sheppard
• Other Authors: University of Bristol
• Format: Article
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/34917
• Institution: Mahidol University

Background and Purpose Loop diuretics are widely used to inhibit the Na+, K+, 2Cl- co-transporter, but they also inhibit the cystic fibrosis transmembrane conductance regulator (CFTR) Cl - channel. Here, we investigated the mechanism of CFTR inhibition by loop diuretics and explored the effects of c...