Carbon monoxide-releasing molecules inhibit the cystic fibrosis transmembrane conductance regulator Cl-channel

• Main Authors: Mayuree Rodrat, Walailak Jantarajit, Demi R.S. Ng, Bartholomew S.J. Harvey, Jia Liu, William J. Wilkinson, Narattaphol Charoenphandhu, David N. Sheppard
• Other Authors: College of Biomedical and Life Sciences
• Format: Article
• Published: 2021
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/60867
• Institution: Mahidol University

© 2020 the American Physiological Society. The gasotransmitter carbon monoxide (CO) regulates fluid and electrolyte movements across epithelial tissues. However, its action on anion channels is incompletely understood. Here, we investigate the direct action of CO on the cystic fibrosis transmembrane...