Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype

• Main Authors: Tyler S. Brown, Christopher G. Jacob, Joana C. Silva, Shannon Takala-Harrison, Abdoulaye Djimdé, Arjen M. Dondorp, Mark Fukuda, Harald Noedl, Myaing Myaing Nyunt, Myat Phone Kyaw, Mayfong Mayxay, Tran Tinh Hien, Christopher V. Plowe, Michael P. Cummings
• Other Authors: University of Bamako Faculty of Medicine, Pharmacy and Odonto-Stomatology
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/35199
• Institution: Mahidol University

© 2015 Elsevier B.V. Multiple transcontinental waves of drug resistance in Plasmodium falciparum have originated in Southeast Asia before spreading westward, first into the rest of Asia and then to sub-Saharan Africa. In vitro studies have suggested that hypermutator P. falciparum parasites may exis...