Cleavage of host cytokeratin-6 by lysine-specificgingipain induces gingival inflammation in periodontitis patients

• Main Authors: Salunya Tancharoen, Takashi Matsuyama, Ko Ichi Kawahara, Kenji Tanaka, Lyang Ja Lee, Miho Machigashira, Kazuyuki Noguchi, Takashi Ito, Takahisa Imamura, Jan Potempa, Kiyoshi Kikuchi, Ikuro Maruyama
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/35201

© 2015 Tancharoen et al. Background/Purpose: Lysine-specific gingipain (Kgp) is a virulence factor secreted from Porphyromonas gingivalis (P. gingivalis), a major etiological bacterium of periodontal disease. Keratin intermediate filaments maintain the structural integrity of gingival epithelial cel...