Modulating glyoxalase i metal selectivity by deletional mutagenesis: Underlying structural factors contributing to nickel activation profiles

• Main Authors: Uthaiwan Suttisansanee, Yanhong Ran, Kadia Y. Mullings, Nicole Sukdeo, John F. Honek
• Other Authors: University of Waterloo
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Materials Science
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/35480
• Institution: Mahidol University

© 2015 The Royal Society of Chemistry. Metabolically produced methylglyoxal is a cytotoxic compound that can lead to covalent modification of cellular DNA, RNA and protein. One pathway to detoxify this compound is via the glyoxalase enzyme system. The first enzyme of this detoxification system, glyo...