Cytotoxic metabolites from the endophytic fungus Penicillium chermesinum: Discovery of a cysteine-targeted Michael acceptor as a pharmacophore for fragment-based drug discovery, bioconjugation and click reactions

• Main Authors: Cici Darsih, Vilailak Prachyawarakorn, Suthep Wiyakrutta, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop
• Other Authors: Chemical Biology Program
• Format: Article
• Published: 2018
• Subjects: Chemical Engineering; Chemistry
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/35696
• Institution: Mahidol University

© The Royal Society of Chemistry 2015. Fungal metabolites (1-8) including known compounds, TMC-264 (1), PR-toxin (6) and a sesquiterpene (7), and new natural products 2-5 and 8, were isolated from the mangrove endophytic fungus Penicillium chermesinum. Compound 2 was a novel tetracyclic polyketide u...