Cytotoxic metabolites from the endophytic fungus Penicillium chermesinum: Discovery of a cysteine-targeted Michael acceptor as a pharmacophore for fragment-based drug discovery, bioconjugation and click reactions

© The Royal Society of Chemistry 2015. Fungal metabolites (1-8) including known compounds, TMC-264 (1), PR-toxin (6) and a sesquiterpene (7), and new natural products 2-5 and 8, were isolated from the mangrove endophytic fungus Penicillium chermesinum. Compound 2 was a novel tetracyclic polyketide u...

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Bibliographic Details
Main Authors: Cici Darsih, Vilailak Prachyawarakorn, Suthep Wiyakrutta, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop
Other Authors: Chemical Biology Program
Format: Article
Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/35696
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Institution: Mahidol University

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