Therapeutic administration of a monoclonal anti-IL-1β antibody protects against experimental melioidosis

• Main Authors: Tassili A.F. Weehuizen, Jacqueline M. Lankelma, Hanna K. De Jong, Onno J. De Boer, Joris J.T.H. Roelofs, Nicholas P. Day, Hermann Gram, Alex F. De Vos, W. Joost Wiersinga
• Other Authors: Academic Medical Centre, University of Amsterdam
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/41122
• Institution: Mahidol University

Copyright © 2016 by the Shock Society. Background: Melioidosis, caused by the gram-negative bacterium Burkholderia pseudomallei, is a common cause of community-acquired sepsis in Southeast Asia and Northern Australia. The NLRP3 inflammasome and its downstream product interleukin-1 beta (IL-1β) have...