Reduced PU.1 expression underlies aberrant neutrophil maturation and function in b-Thalassemia mice and patients

Reduced PU.1 expression underlies aberrant neutrophil maturation and function in b-Thalassemia mice and patients

© 2017 by The American Society of Hematology. β-Thalassemia is associated with several abnormalities of the innate immune system. Neutrophils in particular are defective, predisposing patients to life-Threatening bacterial infections. The molecular and cellular mechanisms involved in impaired neutro...

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Main Authors: Panjaree Siwaponanan, Jurre Ynze Siegers, Razi Ghazali, Thian Ng, Bradley Mccoll, Garrett Zhen Wei Ng, Philip Sutton, Nancy Wang, Isabelle Ooi, Chayada Thiengtavor, Suthat Fucharoen, Pornthip Chaichompoo, Saovaros Svasti, Odilia Wijburg, Jim Vadolas
Other Authors: Royal Children's Hospital, Melbourne
Format: Article
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Immunology and Microbiology
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/41843
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/41843

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