Improving enzymatic activities and thermostability of a tri-functional enzyme with SOD, catalase and cell-permeable activities

• Main Authors: Piriya Luangwattananun, Warawan Eiamphungporn, Napat Songtawee, Leif Bülow, Chartchalerm Isarankura Na Ayudhya, Virapong Prachayasittikul, Sakda Yainoy
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemical Engineering; Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/41922

© 2017 Elsevier B.V. Synergistic action of major antioxidant enzymes, e.g., superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) is known to be more effective than the action of any single enzyme. Recently, we have engineered a tri-functional enzyme, 6His-MnSOD-TAT/CAT-MnSOD (...