Engineering of a novel tri-functional enzyme with MnSOD, catalase and cell-permeable activities

• Main Authors: Piriya Luangwattananun, Sakda Yainoy, Warawan Eiamphungporn, Napat Songtawee, Leif Bülow, Chartchalerm Isarankura Na Ayudhya, Virapong Prachayasittikul
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/43069

© 2016 Elsevier B.V. Cooperative function of superoxide dismutase (SOD) and catalase (CAT), in protection against oxidative stress, is known to be more effective than the action of either single enzyme. Chemical conjugation of the two enzymes resulted in molecules with higher antioxidant activity an...