Increased risk of Thai childhood acute lymphoblastic leukemia with the MiR196a2 T > C polymorphism
Objectives: This study assessed associations of the miR196a2 (rs11614913) T > C polymorphism withsusceptibility to childhood acute lymphoblastic leukemia (ALL) and clinical outcomes. Materials and Methods: Blood DNA samples from 104 childhood ALL patients and 180 healthy children were studied for...
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th-mahidol.419352019-03-14T15:02:57Z Increased risk of Thai childhood acute lymphoblastic leukemia with the MiR196a2 T > C polymorphism Sarinthorn Rakmanee Samart Pakakasama Suradej Hongeng Sirima Sanguansin Acharawan Thongmee Wanida Pongstaporn Rangsit University Mahidol University Biochemistry, Genetics and Molecular Biology Objectives: This study assessed associations of the miR196a2 (rs11614913) T > C polymorphism withsusceptibility to childhood acute lymphoblastic leukemia (ALL) and clinical outcomes. Materials and Methods: Blood DNA samples from 104 childhood ALL patients and 180 healthy children were studied for the miR-196a2 (rs11614913) polymorphism using a polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) approach. Results: The frequency of the miR-196a2 (rs11614913) T allele in controls was 0.51 compared with 0.33 in ALL cases. In this study, CC, TC heterozygote and CC/TC genotypes were significantly associated with increase childhood ALL susceptibility compared with the TT wild type (OR =4.321, 95% CI = 2.091-8.930 p=0.000, OR = 2.248, 95% CI =1.103-4.579, p=0.024, OR = 2.921, 95% CI = 1.504-5.673 p=0.001, respectively). However, the miR-196a2 (rs11614913) T > C polymorphism was not associated with demographic data or clinico-pathological data in ALL cases. Conclusion: CC, TC and CC+TC genotypes of miR-196a2 (rs11614913) was significantly associated with increased susceptibility in Thai childhood ALL but not with clinical variables. 2018-12-21T06:51:56Z 2019-03-14T08:02:57Z 2018-12-21T06:51:56Z 2019-03-14T08:02:57Z 2017-04-01 Article Asian Pacific Journal of Cancer Prevention. Vol.18, No.4 (2017), 1117-1120 10.22034/APJCP.2017.18.4.1117 2476762X 15137368 2-s2.0-85019628742 https://repository.li.mahidol.ac.th/handle/123456789/41935 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85019628742&origin=inward |
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Biochemistry, Genetics and Molecular Biology Sarinthorn Rakmanee Samart Pakakasama Suradej Hongeng Sirima Sanguansin Acharawan Thongmee Wanida Pongstaporn Increased risk of Thai childhood acute lymphoblastic leukemia with the MiR196a2 T > C polymorphism |
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Objectives: This study assessed associations of the miR196a2 (rs11614913) T > C polymorphism withsusceptibility to childhood acute lymphoblastic leukemia (ALL) and clinical outcomes. Materials and Methods: Blood DNA samples from 104 childhood ALL patients and 180 healthy children were studied for the miR-196a2 (rs11614913) polymorphism using a polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) approach. Results: The frequency of the miR-196a2 (rs11614913) T allele in controls was 0.51 compared with 0.33 in ALL cases. In this study, CC, TC heterozygote and CC/TC genotypes were significantly associated with increase childhood ALL susceptibility compared with the TT wild type (OR =4.321, 95% CI = 2.091-8.930 p=0.000, OR = 2.248, 95% CI =1.103-4.579, p=0.024, OR = 2.921, 95% CI = 1.504-5.673 p=0.001, respectively). However, the miR-196a2 (rs11614913) T > C polymorphism was not associated with demographic data or clinico-pathological data in ALL cases. Conclusion: CC, TC and CC+TC genotypes of miR-196a2 (rs11614913) was significantly associated with increased susceptibility in Thai childhood ALL but not with clinical variables. |
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Rangsit University |
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Rangsit University Sarinthorn Rakmanee Samart Pakakasama Suradej Hongeng Sirima Sanguansin Acharawan Thongmee Wanida Pongstaporn |
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Article |
author |
Sarinthorn Rakmanee Samart Pakakasama Suradej Hongeng Sirima Sanguansin Acharawan Thongmee Wanida Pongstaporn |
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Sarinthorn Rakmanee |
title |
Increased risk of Thai childhood acute lymphoblastic leukemia with the MiR196a2 T > C polymorphism |
title_short |
Increased risk of Thai childhood acute lymphoblastic leukemia with the MiR196a2 T > C polymorphism |
title_full |
Increased risk of Thai childhood acute lymphoblastic leukemia with the MiR196a2 T > C polymorphism |
title_fullStr |
Increased risk of Thai childhood acute lymphoblastic leukemia with the MiR196a2 T > C polymorphism |
title_full_unstemmed |
Increased risk of Thai childhood acute lymphoblastic leukemia with the MiR196a2 T > C polymorphism |
title_sort |
increased risk of thai childhood acute lymphoblastic leukemia with the mir196a2 t > c polymorphism |
publishDate |
2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/41935 |
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1763490790848331776 |