Mass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells

• Main Authors: Phatchariya Phannasil, Israr ul H. Ansari, Mahmoud El Azzouny, Melissa J. Longacre, Khanti Rattanapornsompong, Charles F. Burant, Michael J. MacDonald, Sarawut Jitrapakdee
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/41995

© 2016 Elsevier B.V. We recently showed that the anaplerotic enzyme pyruvate carboxylase (PC) is up-regulated in human breast cancer tissue and its expression is correlated with the late stages of breast cancer and tumor size [Phannasil et al., PloS One 10, e0129848, 2015]. In the current study we s...