Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8 + T cell response

• Main Authors: Abigail Culshaw, Kristin Ladell, Stephanie Gras, James E. McLaren, Kelly L. Miners, Carine Farenc, Heleen Van Den Heuvel, Emma Gostick, Wanwisa Dejnirattisai, Apirath Wangteeraprasert, Thaneeya Duangchinda, Pojchong Chotiyarnwong, Wannee Limpitikul, Sirijitt Vasanawathana, Prida Malasit, Tao Dong, Jamie Rossjohn, Juthathip Mongkolsapaya, David A. Price, Gavin R. Screaton
• Other Authors: Imperial College London
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/42733
• Institution: Mahidol University

© 2017 Nature America, Inc., part of Springer Nature. All rights reserved. Adaptive immune responses protect against infection with dengue virus (DENV), yet cross-reactivity with distinct serotypes can precipitate life-threatening clinical disease. We found that clonotypes expressing the T cell anti...