Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group
© 2017 The Author(s). The delivery of safe and effective radical cure for Plasmodium vivax is one of the greatest challenges for achieving malaria elimination from the Asia-Pacific by 2030. During the annual meeting of the Asia Pacific Malaria Elimination Network Vivax Working Group in October 2016,...
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Immunology and Microbiology Kamala Thriemer Benedikt Ley Albino Bobogare Lek Dysoley Mohammad Shafiul Alam Ayodhia P. Pasaribu Jetsumon Sattabongkot Elodie Jambert Gonzalo J. Domingo Robert Commons Sarah Auburn Jutta Marfurt Angela Devine Mohammad M. Aktaruzzaman Nayeem Sohel Rinzin Namgay Tobgyel Drukpa Surender Nath Sharma Elvieda Sarawati Iriani Samad Minerva Theodora Simone Nambanya Sonesay Ounekham Rose Nanti Binti Mudin Garib Da Thakur Leo Sora Makita Raffy Deray Sang Eun Lee Leonard Boaz Manjula N. Danansuriya Santha D. Mudiyanselage Nipon Chinanonwait Suravadee Kitchakarn Johnny Nausien Esau Naket Thang Ngo Duc Ha Do Manh Young S. Hong Qin Cheng Jack S. Richards Rita Kusriastuti Ari Satyagraha Rintis Noviyanti Xavier C. Ding Wasif Ali Khan Ching Swe Phru Zhu Guoding Gao Qi Akira Kaneko Olivo Miotto Wang Nguitragool Wanlapa Roobsoong Katherine Battle Rosalind E. Howes Arantxa Roca-Feltrer Stephan Duparc Ipsita Pal Bhowmick Enny Kenangalem Jo Anne Bibit Alyssa Barry David Sintasath Rabindra Abeyasinghe Carol H. Sibley James McCarthy Lorenz Von Seidlein J. Kevin Baird Ric N. Price Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group |
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© 2017 The Author(s). The delivery of safe and effective radical cure for Plasmodium vivax is one of the greatest challenges for achieving malaria elimination from the Asia-Pacific by 2030. During the annual meeting of the Asia Pacific Malaria Elimination Network Vivax Working Group in October 2016, a round table discussion was held to discuss the programmatic issues hindering the widespread use of primaquine (PQ) radical cure. Participants included 73 representatives from 16 partner countries and 33 institutional partners and other research institutes. In this meeting report, the key discussion points are presented and grouped into five themes: (i) current barriers for glucose-6-phosphate deficiency (G6PD) testing prior to PQ radical cure, (ii) necessary properties of G6PD tests for wide scale deployment, (iii) the promotion of G6PD testing, (iv) improving adherence to PQ regimens and (v) the challenges for future tafenoquine (TQ) roll out. Robust point of care (PoC) G6PD tests are needed, which are suitable and cost-effective for clinical settings with limited infrastructure. An affordable and competitive test price is needed, accompanied by sustainable funding for the product with appropriate training of healthcare staff, and robust quality control and assurance processes. In the absence of quantitative PoC G6PD tests, G6PD status can be gauged with qualitative diagnostics, however none of the available tests is currently sensitive enough to guide TQ treatment. TQ introduction will require overcoming additional challenges including the management of severely and intermediately G6PD deficient individuals. Robust strategies are needed to ensure that effective treatment practices can be deployed widely, and these should ensure that the caveats are outweighed by the benefits of radical cure for both the patients and the community. Widespread access to quality controlled G6PD testing will be critical. |
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Menzies School of Health Research |
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Menzies School of Health Research Kamala Thriemer Benedikt Ley Albino Bobogare Lek Dysoley Mohammad Shafiul Alam Ayodhia P. Pasaribu Jetsumon Sattabongkot Elodie Jambert Gonzalo J. Domingo Robert Commons Sarah Auburn Jutta Marfurt Angela Devine Mohammad M. Aktaruzzaman Nayeem Sohel Rinzin Namgay Tobgyel Drukpa Surender Nath Sharma Elvieda Sarawati Iriani Samad Minerva Theodora Simone Nambanya Sonesay Ounekham Rose Nanti Binti Mudin Garib Da Thakur Leo Sora Makita Raffy Deray Sang Eun Lee Leonard Boaz Manjula N. Danansuriya Santha D. Mudiyanselage Nipon Chinanonwait Suravadee Kitchakarn Johnny Nausien Esau Naket Thang Ngo Duc Ha Do Manh Young S. Hong Qin Cheng Jack S. Richards Rita Kusriastuti Ari Satyagraha Rintis Noviyanti Xavier C. Ding Wasif Ali Khan Ching Swe Phru Zhu Guoding Gao Qi Akira Kaneko Olivo Miotto Wang Nguitragool Wanlapa Roobsoong Katherine Battle Rosalind E. Howes Arantxa Roca-Feltrer Stephan Duparc Ipsita Pal Bhowmick Enny Kenangalem Jo Anne Bibit Alyssa Barry David Sintasath Rabindra Abeyasinghe Carol H. Sibley James McCarthy Lorenz Von Seidlein J. Kevin Baird Ric N. Price |
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Kamala Thriemer Benedikt Ley Albino Bobogare Lek Dysoley Mohammad Shafiul Alam Ayodhia P. Pasaribu Jetsumon Sattabongkot Elodie Jambert Gonzalo J. Domingo Robert Commons Sarah Auburn Jutta Marfurt Angela Devine Mohammad M. Aktaruzzaman Nayeem Sohel Rinzin Namgay Tobgyel Drukpa Surender Nath Sharma Elvieda Sarawati Iriani Samad Minerva Theodora Simone Nambanya Sonesay Ounekham Rose Nanti Binti Mudin Garib Da Thakur Leo Sora Makita Raffy Deray Sang Eun Lee Leonard Boaz Manjula N. Danansuriya Santha D. Mudiyanselage Nipon Chinanonwait Suravadee Kitchakarn Johnny Nausien Esau Naket Thang Ngo Duc Ha Do Manh Young S. Hong Qin Cheng Jack S. Richards Rita Kusriastuti Ari Satyagraha Rintis Noviyanti Xavier C. Ding Wasif Ali Khan Ching Swe Phru Zhu Guoding Gao Qi Akira Kaneko Olivo Miotto Wang Nguitragool Wanlapa Roobsoong Katherine Battle Rosalind E. Howes Arantxa Roca-Feltrer Stephan Duparc Ipsita Pal Bhowmick Enny Kenangalem Jo Anne Bibit Alyssa Barry David Sintasath Rabindra Abeyasinghe Carol H. Sibley James McCarthy Lorenz Von Seidlein J. Kevin Baird Ric N. Price |
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Kamala Thriemer |
title |
Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group |
title_short |
Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group |
title_full |
Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group |
title_fullStr |
Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group |
title_full_unstemmed |
Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group |
title_sort |
challenges for achieving safe and effective radical cure of plasmodium vivax: a round table discussion of the apmen vivax working group |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/42843 |
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1763497957802377216 |
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th-mahidol.428432019-03-14T15:03:53Z Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group Kamala Thriemer Benedikt Ley Albino Bobogare Lek Dysoley Mohammad Shafiul Alam Ayodhia P. Pasaribu Jetsumon Sattabongkot Elodie Jambert Gonzalo J. Domingo Robert Commons Sarah Auburn Jutta Marfurt Angela Devine Mohammad M. Aktaruzzaman Nayeem Sohel Rinzin Namgay Tobgyel Drukpa Surender Nath Sharma Elvieda Sarawati Iriani Samad Minerva Theodora Simone Nambanya Sonesay Ounekham Rose Nanti Binti Mudin Garib Da Thakur Leo Sora Makita Raffy Deray Sang Eun Lee Leonard Boaz Manjula N. Danansuriya Santha D. Mudiyanselage Nipon Chinanonwait Suravadee Kitchakarn Johnny Nausien Esau Naket Thang Ngo Duc Ha Do Manh Young S. Hong Qin Cheng Jack S. Richards Rita Kusriastuti Ari Satyagraha Rintis Noviyanti Xavier C. Ding Wasif Ali Khan Ching Swe Phru Zhu Guoding Gao Qi Akira Kaneko Olivo Miotto Wang Nguitragool Wanlapa Roobsoong Katherine Battle Rosalind E. Howes Arantxa Roca-Feltrer Stephan Duparc Ipsita Pal Bhowmick Enny Kenangalem Jo Anne Bibit Alyssa Barry David Sintasath Rabindra Abeyasinghe Carol H. Sibley James McCarthy Lorenz Von Seidlein J. Kevin Baird Ric N. Price Menzies School of Health Research National Vector Borne Disease Control Programme National Center for Parasitology, Entomology and Malaria Control National Institute of Public Health International Centre for Diarrheal Diseases and Research Universitas Sumatera Utara Mahidol University Medicines for Malaria Venture (MMV) PATH Mahidol-Oxford Tropical Medicine Research Unit Nuffield Department of Clinical Medicine Ministry of Health and Family Welfare Ministry of Health in Bhutan Ministry of Health and Family Welfare National Malaria Control Program National Center for Entomology Parasitology and Malaria Control Kementerian Kesihatan Malaysia Minister for Health and Population Nepal National Malaria Control Programme Department of Health Manila Korea Centers for Disease Control & Prevention Ministry of Health Colombo Thailand Ministry of Public Health National Malaria Control Programme National Institute of Malaria, Parasitology, and Entomology (NIMPE) Access Bio Inc Australian Army Malaria Institute Burnet Institute Ministry of Health, Republic of Indonesia Indonesian Medical Association Eijkman Institute of Molecular Biology FIND Jiangsu Institute of Parasitic Diseases Karolinska Institutet Osaka City University Wellcome Trust Centre for Human Genetics Wellcome Trust Sanger Institute Malaria Consortium Indian Council of Medical Research Yayasan Pengembangan Kesehatan dan Masyarakat Papua Timika Gokila Walter and Eliza Hall Institute of Medical Research University of Melbourne United States Agency for International Development Organisation Mondiale de la Santé WWARN University of Washington, Seattle QIMR Berghofer Medical Research Institute Eijkman-Oxford Clinical Research Unit Immunology and Microbiology © 2017 The Author(s). The delivery of safe and effective radical cure for Plasmodium vivax is one of the greatest challenges for achieving malaria elimination from the Asia-Pacific by 2030. During the annual meeting of the Asia Pacific Malaria Elimination Network Vivax Working Group in October 2016, a round table discussion was held to discuss the programmatic issues hindering the widespread use of primaquine (PQ) radical cure. Participants included 73 representatives from 16 partner countries and 33 institutional partners and other research institutes. In this meeting report, the key discussion points are presented and grouped into five themes: (i) current barriers for glucose-6-phosphate deficiency (G6PD) testing prior to PQ radical cure, (ii) necessary properties of G6PD tests for wide scale deployment, (iii) the promotion of G6PD testing, (iv) improving adherence to PQ regimens and (v) the challenges for future tafenoquine (TQ) roll out. Robust point of care (PoC) G6PD tests are needed, which are suitable and cost-effective for clinical settings with limited infrastructure. An affordable and competitive test price is needed, accompanied by sustainable funding for the product with appropriate training of healthcare staff, and robust quality control and assurance processes. In the absence of quantitative PoC G6PD tests, G6PD status can be gauged with qualitative diagnostics, however none of the available tests is currently sensitive enough to guide TQ treatment. TQ introduction will require overcoming additional challenges including the management of severely and intermediately G6PD deficient individuals. Robust strategies are needed to ensure that effective treatment practices can be deployed widely, and these should ensure that the caveats are outweighed by the benefits of radical cure for both the patients and the community. Widespread access to quality controlled G6PD testing will be critical. 2018-12-21T08:00:09Z 2019-03-14T08:03:53Z 2018-12-21T08:00:09Z 2019-03-14T08:03:53Z 2017-04-05 Article Malaria Journal. Vol.16, No.1 (2017) 10.1186/s12936-017-1784-1 14752875 2-s2.0-85016978562 https://repository.li.mahidol.ac.th/handle/123456789/42843 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85016978562&origin=inward |